Stromal tumor; Gonadal stromal tumor; Sex cord tumor; Androblastoma
Causes, incidence, and risk factors
This is a rare tumor. It accounts for less than 0.5% of all ovarian tumors.
These tumors are found in women of all age groups, but are most common in young women.
This tumor releases male hormones, which causes the following symptoms in women:
Deepening of the voice
Increased hair on the face and body
Increased size of the clitoris
Male pattern baldness
Signs and tests
Blood tests to check levels of hormones that may be released by the tumor
CT scan of the pelvis and abdomen to see if the tumor has spread
Ultrasound of the ovaries
Surgery to remove the tumor is the main treatment. If the cancer has spread, chemotherapy or radiation therapy may be considered.
You can ease the stress of illness by joining a support group where members share common experiences and problems. See cancer - support group.
The outcome of this disease depends on whether it has spread, and whether surgery can completely remove the tumor.
Arrhenoblastoma has a low chance of spreading. If the tumor is found early, the cure rate can be very good.
Complications of surgery
Masculine symptoms (virilization)
Spread of the tumor if it is not completely removed
Calling your health care provider
Call your health care provider if you are a woman and have masculine symptoms, or you feel a lump in your lower belly area.
There is no good screening test. Regular gynecologic exams and recognizing masculine symptoms may help detect the disease.
Bulun SE, Adashi EY. The physiology and pathology of the female reproductive axis. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 17.
Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington. Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Bellevue, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.